It’s been a long while since I was on Humira, and I only lasted 4 months. So I don’t remember specifically how I felt. I am on Remicade now, and for the first year I typically felt as though I had a mild flu for the first couple of days after each infusion. That happens less now. Given what either med is changing in your body, I would be surprised if you didn’t have some reaction. But talk with your provider and see if your having normal symptoms. And what you can do about it.