I can tell u that I'm on a antidepressant; it's a very low dose. My dr advised me it's like a maintenence drug. This disease can & will run u down physically & mentally. I have a Jpouch, in the beginning years it nearly took me over the edge. I believe in meds, definitely to relax me when it's a really hard day & night. I take vitamins too. Find a diet that fits for u & exercise is a must. Even at that it's a struggle but liveable. Best wishes & know this group is a life saver. Prayers for u. That's my #1 savior.