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Reply to "How long is this Pouchitis going to last?"

I have been treating pouchitis for 17 years with antibiotics. It responds to the treatment and is kept in a "simmering state", meaning it is there and never fully goes away but is kept in check. If I am off antibiotics for a week my sypmtoms deteriorate rapidly to the point where things are not tolerable.

Some pouchitis cases can be treated once or twice with antibiotics, some require chronic treatment. In my case 17 years of documented inflammation in my pouch but I still have the pouch for 20 years now.

I rotate antibiotics: cipro/flagyl, xifaxin, augmentin, usually 3 weeks of each but I am reducing now to a rotation every week.

It sounds to me like xifaxin may not be working for you. You may need to try other antibiotics. Cipro and flagyl in tandem are my most effective antibiotic "cocktail".
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