The usual dosing of cefuroxime for generic infections is 250-500 mg twice daily. I don’t know how important it is to take twice daily - I used trial & error (actually just trial) to determine that my Cipro and Flagyl work just as well *for my pouchitis* taken once daily, and that makes it much easier to space them away from interacting foods. I have no idea how cefuroxime behaves with long term use, but your doctor probably doesn’t, either, since it’s almost never used that way.