I take the probiotic in yogurt with breakfast and dinner, and the the antibiotics at bedtime.
The advantage to starting at a low dose is that it minimizes the potential for trouble. The disadvantage is that it can take a long time, with many days of treatment to find out if the drug does any good at all.
Conversely, the advantage to starting at a higher dose (intending to drop it) is you may know rather quickly if there’s any point to continuing the medication. You know the disadvantages of the higher dose, of course.