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Reply to "General comment on pouchitis"

Pepto Bismol is very effective at combatting Pouchitis because of its bactericidal properties, but what I think it does is thicken stools rather than slows down motility, as does Imodium. My question to the other posters in this thread is whether they are also taking Imodium which does slow down motility. Bismuth subsalicylate changes the balance of fluids in the intestine which is a different mechanism of action that results in thickening of the stools. If the other posters are taking Imodium, opioids or other bowel slowers, they are blaming PB for the mechanism of action of another drug.

Of course, thickening the stool as opposed to slowing transit times creates the same problems for someone prone to obstruction, so if that is the bottom line concern, the differences in mechanism of action do not matter. It is important however to understand how these drugs all work.

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