@qdm posted:Thank you for this helpful feedback. I have taken large doses of PPIs for over two years now. Either pantoprazole (40 mg twice a day) or omeprazole (20 mg twice a day). I rotate about every six months if seems to stop working. That seems like a lot, correct?
Yes, that’s a lot of acid blocking. If you’re having breakthrough pain (which is what it sounds like to me), then it could be a few things. You might need to try a different acid blocker (i.e. they aren’t working any more), you might have gastritis or esophagitis or an ulcer, or one or two other things. I was in a similar situation earlier this year and I chose to have an upper GI endoscopy, mainly to ensure that my years of reflux hadn’t caused a Barrett’s esophagus, which presents a cancer risk.