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Reply to "Flagyl versus cipro"

herb ear posted:

Thank you, how about cipro & xifaxan combo?

I would never take xifaxin in combination with any antibiotic for the reason that it’s not systemically absorbed and if you have to take antibiotics chronically it’s something that gives your system a breather from the other systemically absorbed antibiotics.

Back in the 1990s flagyl always would get prescribed first and cipro second. My GI from 1992 to 2009 was the go to GI for many  Mount Sinai J Pouch patients in NYC including myself. He noted that in patients who could handle both flagyl and cipro without significant side effects, that using the two drugs in tandem, as a “cocktail”, produced much better results than used alone. The reason why is they are different antibiotic families and work on different bacteria groups that cause Pouchitis, both of which are present in many Pouchitis cases.

He encouraged me to try the “cocktail” when I became chronic and it worked much better than either antibiotic taken alone. 

He also cautioned me to never use cipro with levacquin (same family of antibiotics, so it’s like incest among antibiotics to use them together). He suggested I go from cipro and flagyl to xifaxin or some other antibiotic when I rotated and not right to levacquin. Levacquin can also be used with flagyl. 

If you have to take antibiotics chronically it’s important to understand how they work and on what bacteria, and your body’s reaction to each of them, and from there you can develop a plan.

I always thought of Cipro and Flagyl like Gin and Tonic, or Batman and Robin, or Simon and Garfunkel- just a famous duo that worked well together.

Last edited by CTBarrister
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