I started taking an anticonvulsive in time-release format in the early '90s...we couldn't figure out why they were not working...until I found myself unconscious for 4 days...they were sitting in my pouch for weeks and suddenly dissolved (probably when I ate something very acidic like pineapple) all at once...
Since then I take nothing, absolutely nothing in time-release formulas...even my B-complex vitamins are now off of the list...they just do not dissolve.
Sharon