I have begun treatment with the Entyvio. Received my second dose today. So far, positive results. Tapering off of the steroids. Through my 18+ year history with colitis and a colectomy I have taken all of the biologics, steroids and know Entyvio. They all have potential long term affects and my colectomy was done because I had developed colon cancer, in addition to chronic coilitis. Whther any of the medications caused or effected the cancer is unknown. At this point in my life, age 70, I just want as much relief as I can get and am willing to deal with possible, unknown and , in my view , unlikely serious side effects of Entyvio.