I stopped taking Rifaximin a year ago because I had been on it since 2003 and was having distention issues. (went to Mexico to get it before it was available here.) The distention cleared up but my recent pouchoscopy showed severe inflammation and ulcerations. I consulted a doctor other then my own and also my own. Both recommended Entyvio. But I had an allergic reaction to remicade and was hospitalized for 12 days and required open lung biopsies and other horrible tests so I am trying to stay away from biologics. Both doctors agreed I could try rifaximin again and in two weeks add VSL3. Apparently there was a study for treating pouchitis with an exact protocol of 1 gram daily of rifaximin followed by VSL3 so I will try that first. I am also trying hard to get into FMT studies for pouchitis or get FMT treatment as I believe that will help the most.