I am using it now for nearly a year. I had chronic pouchitis for years now. The result is a mixed bag for me. Initially it helped to reduce my symptoms but did not resolve them. However a pouchoscopy showed a nearly perfect pouch (compared to a badly inflamed, ulcerated one last year). That was very encouraging. After a few months the symptoms increased and I assumed the drug stopped working and I went to do another pouchoscopy, however once again it showed a nearly perfect, healed pouch. So the drug certainly is able to clinically clean up or stop the inflammation but it does not address the root cause of this disease, which still causes urgency, frequent bathroom visits and discomfort. Now I take Amitriptyline, that helps a bit controlling urgency, but still not enough.