Biologics are usually last line or last resort drugs, but Remicade is not usually administered the way your doctors did it, and there should not have been any expectation of instant results if you were really sick. Sorry to hear about that Bent-Arne. It's possible you were headed for surgery anyway, and their rationale was "nothing ventured, nothing gained" and you did not have months to wait it out. It may or may not have helped if it had been administered as it usually is, and if you did not have months to wait it out, they could have ended up eventually performing an emergency surgery on you after your colon perforated. So I can kind of understand their out of the box thinking. I was very close to that status when I had surgery, but Remicade did not exist at that time in the USA. It only came to market in 1998 or 1999. So I was past saving (from surgery) anyway. They tried Imuran on me before my surgery, and my liver chemistries were sent sky high, so that was the last ditch fail in my case.