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Reply to "Cuffitis"

For me mesalamine also had side effects like a foggy brain and light fever. My pouchitis / cuffitis was kept in check with budesonide (Entocort) for many years. I still take a small dose of 3 mg every day. It takes effect mainly locally at the end of the small intestine and pouch. Yet it has only a calming effect for me, it does not heal inflammation.

I also had c.diff from taking Cipro & Flagyl, but I continued with those meds after treating c.diff with another antibiotic, because they always helped me best. I reduced the dose (only once a day at lake evening) and added a probiotic in the morning.

So I would suggest trying an antibiotic that you can tolerate well, perhaps even Cipro (in combination with a probiotic?). As you are already dealing with cuffitis for some time, you may ask your GI doc if a treatment for at least 3 weeks would be appropriate (as the recommendation for an initial treatment is already 2 weeks).

Budesonide orally (capsules) or as an enema is also an option.

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