Hi cb,
Cuffitis started for me very quickly after takedown and I have been on canasa suppositories ever since with good success.
I am so sorry that mesalamine does not work for you, as that seems to keep my cuffititis in check. My recent scope showed no inflammation but the biopsies still show microscopic colitis in the cuff.
Having said all that, I am not willing to ever have surgery again, so I will do whatever it takes to avoid a repeat of dysplasia in that area. I even asked my GI if we should be stepping up the therapy to a biological; he said no, the canasa is keeping the inflammation in check.
I see a doctor at a specialty center at a university hospital, so I am very comfortable with his treatment plan and recommendations.
If I were in your situation , I would absolutely find someone more experienced with pouchers. Since I have not used antibiotics for my cuffitis, I have no opinion as to their efficacy. But since you are suffering you should have an ally working with you who has seen enough pouchers to know what works in your situation.