I take methotrexate 15 mg once a week which is designed to suppress renal secretions of the Remicade and also take prescription folic acid to counteract the effects of the Methotrexate. As I said no issues and all of my blood labs are clean for 3 years. I should note that Imuran sent my liver chemistries haywire in the 1990s but no such issues with these meds.
You keep talking about “unpleasant side effects”, I have had none in 3 years. I see many many patients in the Remicade room and while I don’t know what their specific histories are they all have IBD and all report doing well. I have been in Remicade rooms with 4 patients at a time every 6 weeks for 3 years and never witnessed any infusion complications either.
You also shouldn’t worry about antibody development because if it happens you go to Entyvio or 2-3 others. There are many biological drugs that can be used in lieu of Remicade. Talk to your doctor about it. We discussed Entyvio as my plan B but have never needed plan B. Plan C and D were also discussed. Still on plan A so I don’t worry about those things.