Betty Boo, I’m only using sulfasalazine for the enteropathic arthritis—I haven’t noticed any effect on my pouchitis or cuffitis symptoms. I just came off a Cipro regimen and got frequency down significantly but like you, it’s starting to creep back up. I’m using Visbiome ES 2x a day but may ask my doc about rotating antibiotics if I don’t keep it under control.