Jovic.......I have been on Advair and Atrovent for quite some time. I am not on Prednisone normally but have been given it if my breathing problems escalate. It's been awhile. Meanwhile, I now swear by nebulized saline. I use it first thing in the a.m. along with my Hil-Rom vest. Between the two treatments it loosens mucus and allows me to easily get rid of it. I follow this with my Advair and Atrovent treatment. Then, in the late afternoon, I repeat the vest and nebulizer. I finally sleep all night without having to clear my lungs! I never feel congested! It has been a miracle. Not only has this saline treatment been beneficial, it is also very, very cheap!