I have chronic pouchitis. I started with 500mg Cipro twice a day. It worked for awhile and then I started getting symptoms. I tried switching to flagyl. That didn't work. So I now do Cipro in the morning and flagyl at night. I've been on these since February 2019 and haven't had any side effects. I was able to lower the dosage to 250mg each. I eventually got off both for about a month before the pouchitis returned. I'm back to 500mg of each. Hoping to get back to 250 each and that's where I'll stay.