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Cipro isn't working anymore for my Chronic Pouchitis

I am looking for other peoples perspectives here.  I have been on Cipro (500 mg/2x per day for 8 years as maintenance for chronic pouchitis.  It started quickly after my surgeries and never resolved until it stayed on Cipro. The last three weeks have been rough and it seems pouchitis is showing up again.  Telltale signs for me; stomach aches, watery stool all the time, more frequency, and night time accidents.  My doctor has now started a course of Metronidazole (500 mg 2/day) in addition the Cipro.  I am concerned, feels like a lot of antibiotics and what happens if I become anti biotic resistant?  I've only been on it a day so too early to tell if it is helping (although the warning label also concerned me).

I have read a few posts about Remicade which I had used back when I was in active flare of UC but it stopped working after six months and I ended up with an emergency colon removal and subsequent j pouch, so when it comes to biologics, I doubt that's an option. 

Welcome peoples thoughts and perspectives - are there a lot of options left for me or do I have to worry about this pouch lasting?  Concerned.

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