My new GI highly advised I go on Cipro/Flagyl "rotation" after using only Flagyl for a few years (daily) for chronic pouchitis. It's efficacy was starting to wane anyhow, so I took his advice. Pouchitis always returns when stopping antibiotic. I switch off every 90 days.Cipro makes me feel a little better and it gives me slightly better control. No pouchitis for 1 1/2 years but 6-8 bm is still the norm