Hi Anthony. I've had chronic pouchitis for the last 1.5Yrs and there were long stretches in the "C" category. About three months ago Dr. Shen prescribed me Tinidazole, an antibiotic, which I am on long term. I was wary about it losing efficacy so I spoke to his nurse who ensured me that they've had patients who have had long term success with the antibiotic. My other GI doc put me on Humira about the same time. It's like a light switch has been flipped. I went from having urgency and nightly problems to now going 6x/day, once or twice at night. This was a huge improvement for me. I had developed fistulas and those have healed, not altogether but better than before. I've gained about 25lbs in three months and my strength and endurance have significantly improved. I recommend asking your doc about Tinidazole.