Idk, I pass one of my medications every morning within 2-3 hours- I always see it come out in my stool. I told my doc and they upped my dosage of the medication to make sure I’m getting the correct amount (it’s my anti-depressant since it’s a delayed release tab). They said they do that for people who have gastric bypass and people without a colon since it may pass too quickly. My Colestipol also does that- it’s a HUGE tablet and doesn’t dissolve all the way. I guess we never really know unless we see it in the toilet bowel.