Thank you guys for both responding. My doctor isn't picking Entyvio over other ones for me, but rather recommending it first because it's a "biologic that should have less risk of side effect" after I stressed my hesitation for biologics in general. He said it targets the body in a different way which leads to less severe side effects, but I don't know how proven it is right now. I was recommended Remicade before my surgeries, but I was hesitant to start because it was somewhat new at the time and I didn't know how well it would work over time as I was only 22 at the time. Due to insurances still factoring in pre-existing conditions, I chose to have surgery while I was still on my parent's insurance. I want to trust Remicade now because it has been around for a long time and is proven to work with most, but I'm worried about getting side effects or making things worse for myself. I already feel like I'm hanging by a string with the side effects I've had from j-pouch surgery, so I don't know that I can take on any more issues. I'm trying to make a better life for myself with going on biologics, but I'm hesitant because I don't know what I'll do if they don't work.