I've been through the rounds with first a UC diagnosis and now Crohns. (Some of us are just lucky that way!) Anyway I have also been down the biologic path. My doctor started with Humira and I did that for a couple of years, but it didn't really help the inflammation. Next, I was on Remicade, but unlike CT, I had a terrible reaction to it. (Severe muscle and joint pain plus I tried to pass out after the second infusion. I just felt terrible after each infusion and it lasted for a couple of days. ) I'm currently on Entyvio and will see how that is working after my next scope in April. So far I've not had any reactions to it.
One advantage I see to Entyvio is that it targets the gut rather than all across the body. I must admit I also like the shorter infusion time.
Whatever biologic you choose, make sure you ask a lot of questions so you feel comfortable with what the on going plan will be. All of the above biologics have programs to help pay for them. Make sure you ask about them with your infusion or injection provider.