Canasa probably won’t directly help a fissure. On the other hand, successfully treating a fissure includes 1) managing stool texture - you want soft rather than liquid or hard, 2) avoiding straining, 3) sitz baths, and 4) medication, e.g. nitroglycerin/Rectiv or nifedipine or diltiazem or even Botox. I could imagine successful cuffitis treatment with Canasa providing some help with 1 and 2.