I have been on one biologic or another since 2005. No side effects or issues, other than a loss of effectiveness over time. I am currently on Inflectra (biosimilar of Remicade). Since starting Remicade about 3-4 years ago, my chronic pouchitis is under control and my arthritis is manageable.
So, yeah, I would say it is a success for me. The primary downside is the hassle of frequent blood tests and having infusions every 6 weeks. I just have to plan my travels around it.
Jan