I do the expensive VSL3 as well. Have never been able to conclusively know whether it helps but my GI is very in favor of it. And I'm on Humira as @kta mentioned.
For me, my onsets/treatments were :
-soon after surgeries abscesses/cuffitis - Canasa GREATLY helps me with cuffitis. Helped me immediately years ago and still helps me greatly ~10 years later.
-later ~5 years after surgeries added fistula(s) to mix- ultimately added Humira to address abscesses/fistulas and going on 2.5 years of Humira w no abscesses/fistulas now knock on wood.
-chronic pouchitis in last few years - long term antibiotics.
I'm over 10 years with pouch and despite it being ongoing chronic multi-threaded challenge (above) I'm still glad I went pouch route. Currently feeling like the chronic pouchitis is my biggest demon to battle.