I would say yes, you are ready. It seems like you have tried a variety of treatments and given everything a fair go. Despite everything that has been done, you still haven't achieved remission and you are continuing to have flares. It's unlikely your UC will improve with the current course, and I would say you will probably only get worse, considering your system is no longer responding to treatments that worked in the past. In my own situation, I deteriorated in matter of weeks, to the point that my surgery ended up being on an emergency basis. Believe me, you do not want to go that route if you don't have to. You have a far better chance at a quicker and more successful recovery if you go into your surgery relatively healthy. So, I would say if you are at the point that you are considering it, then you already know the other options have failed or are likely to fail. You're also saying to yourself that you've had enough. So why not go for it? You could have a whole new quality of life waiting for you.