Right from the start I was allergic to mesalamine. Had to have a picc line inserted for direct steroids. When that wasn’t enough, I started Rremicade. I had another reaction to Remicade and couldn’t try another immunosuppressant drug (like Humira) because I was underage. Since it was my last option before surgery, my doctor started to give me a large dose of steroids before my infusion therapy to combat any reaction. That worked for me for a couple of years and I definitely would recommend trying this before resorting to surgery.