Update: I've been doing the enemas nightly for almost 2 weeks. I haven't really noticed any change. Well, I shouldn't say that--I've had okay days. Still haven't gotten my bathroom trips below 9 per day, and still averaging about 11. I'm reading here that some people don't feel the effect for 3 weeks, so I'll stick with it and try to stay optimistic. Right now my biggest fear is that I'm getting the drug and not responding. Never thought I'd hope to be in the placebo group! It will be months before I can go open label. Onward.