I had J-pouch surgery 19 years ago due to severe ulcerative colitis. I developed chronic pouchitis and resulted in a Crohn's diagnosis since the inflammation had spread to small intestine a bit. My current situation is that I take 500 mg Cipro, 500 mg Flagyl, and small dose of Lomotil every day; receive Entyvio infusions every 8 weeks. This combo has done the trick for me. Would love to get off of Flagyl so I can enjoy the occasional glass of wine, but every time I have tried, I experience symptoms again....sigh