Reply to "Too soon to abandon Humira?"

Jan DollarModerator, RN, retired

You can develop antibodies to any biologic, but they are specific to the biologic, just like immunity is specific to individual viruses. Using Imuran or methotrexate can help reduce the risk of antibody formation.

That said, it is true that young males (35 and younger) are at a higher risk for lymphoma with combination therapy with azathioprine (Imuran) and similar drugs. Methotrexate (MTX) combination therapy does not seem to have the same risk profile, but is not as effective. No easy answers to be sure!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950663/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123358/

Jan

3/12/1812:36 AM

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