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Reply to "Methotrexate and hydration"

I take Methotrexate (12.5 mg or 5 pills once weekly) with Remicade and have not noticed any unusual dehydration. I have pretty good hydration hygiene generally and it has been a non issue. By the way you should take Folic Acid to counteract other possible side effects of Methotrexate. The most notable of which are cold sores in the mouth. I developed them when I didn’t take the Folic Acid a few days. If I take Folic Acid daily, there are no issues.

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